The science that will change cardiology.
Our therapeutic and diagnostic research spans the full spectrum of cardiovascular disease, from the genetic roots of atherosclerosis to AI-driven imaging that detects disease before symptoms appear.
Featured
Gene Silencing
Partnering on first-in-human gene-editing and gene-silencing therapies that address the genetic roots of cardiovascular disease — a generational leap beyond surrogate treatments.
Featured
Eradication & Mitigation of Coronary Artery Disease
A novel multi-pathway strategy — combining plaque-directed therapy, polygenic risk scores, AI-CCTA monitoring, and genetic intervention — designed to move CAD from chronic disease to preventable condition.
Imaging
Coronary CT Angiography (CCTA)
Pioneering work that significantly improved how clinicians decide who needs stenting, who needs surgery, and who is best served with continued medical therapy.
AI
AI-Driven Plaque Analysis
Among the first centers in the world to apply machine learning to post-cardiac CT processing — directly contributing to multiple FDA clearances for cardiac AI software.
Lipidology
Lipoprotein(a) & Lipid Disorders
Investigator work on elevated Lp(a) — one of the most underrecognized inherited cardiovascular risk factors — and the therapies designed to lower it.
Heart Failure
HFpEF & Metabolic Disease
Cardiometabolic research on heart failure with preserved ejection fraction — including pacemaker-algorithm work for patients with normal heart function.
Inflammation
Vascular Inflammation
Research on the inflammatory pathways that drive atherosclerosis, plaque instability, and acute cardiac events — including PET-based assessment of vascular inflammation.
Imaging
Nuclear Cardiology & F-18 Imaging
Pioneering the next generation of advanced isotopes, including F-18 cardiac imaging agents — reshaping early detection with superior resolution and lower radiation.
EP
Electrophysiology & Device Science
Internationally recognized work on ICD therapy, pacemaker lead reliability, and the algorithmic improvements that reduce inappropriate shocks for the millions of patients living with defibrillators.
Structural
Calcific Aortic Valve Disease
Investigator participation in studies of therapies that may slow or modify the progression of calcific aortic valve stenosis.
Vascular
Abdominal Aortic Aneurysm
Engagement with industry partners on therapies aimed at reducing the progression of infrarenal abdominal aortic aneurysm.
Women’s Health
Small-Vessel & Macrovascular Angina
Landmark work on women’s small-vessel disease and macrovascular angina — reshaping how clinicians evaluate chest pain unrelated to large-vessel obstruction.
Wearables
Wearable & At-Home Monitoring
Wrist-based devices for at-home troponin monitoring and ambulatory cardiac rest therapy — bringing the clinic to the patient.
Multimodal
Whole-Body MRI & Multi-Modality Imaging
Integrating CCTA, nuclear imaging, MRI, and AI quantification into a unified diagnostic platform built around the patient.
Devices
Interventional Cardiology Precision
Novel software approaches combining angiography, intravascular ultrasound, and CCTA — reducing procedural complications during stent placement.